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Therefore identification of the novel drug target and potent drug can be helpful in better prevention of the disease. Alter et.al, (2008) Leprosy as a genetic model for susceptibility to common infectious disease, Hum Genet 2. (1999)Health Policy and Planning; 14(2): 89-102, Oxford University Press.

The bacteria have developed resistance against many of the drugs available in the market.

Gaing, "Particle Swarm Optimization to solving the economic dispatch considering generator constraints," IEEE Trans.

Key words: docking, homology modeling, leprosy, M.leprae, molecular, molecular dynamics, ramachandran plot.

Halgamuge "Self-Organizing Hierarchical Particle Swarm Optimizer With Time Varying Acceleration Coefficients" IEEE Trans. A well organized research comprising of analogue based drug design and molecular dynamics plays a major role in obtaining the lead molecules. Black PN, Di Russo CC, Metzger AK, Heimert TL (1992): Cloning, sequencing, and expression of the fad D gene of Escherichia coli encoding Acyl coenzyme A Synthetase.

The organism requires minimal set of functional genes for its survival. Bateman A, Birney E, Cerruti L (2002).‖The Pfam Protein Families Database‖. Two kinds of improved evolution rules are proposed to replace the rule in regular cellular genetic algorithm, in which null cells are considered to the foods of individuals in population and the maximum of living individuals in cellular space is limited by their food. Key words: Computational Hydraulic, Energy Efficient Actuators, Energy Saving in Hydraulic, Hydraulic Control Reference [1] P. Krus, "On Load Sensing Fluid Power Systems," Division of Fluid Power Control Department of Mechanical Engineering, Linkoping University, Sweden, 1988. Abstract: Analysis of the robot hand was analyzed using dedicated software for FEM analysis. in ANSYS, the geometry was updated and the structure meshed using 3D elements. Economic Load Dispatch(ELD) is one of important tasks which provide an economic condition for a power system. Stukenbrock, "Toward maximum flexibility in working machinery, iht control in a mecalac excavator," 2004. Yao, "Energy-saving control of singlerod hydraulic cylinders with programmable valves and improved working mode selection," 2002. Eriksson, "Control Strategy for Energy Efficient Fluid Power Actuators: Utilizing Individual Metering," SE-581 83 Linköping, Sweden: Linköping University, 2007. There are various field of power system in which PSO is successfully applied.

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Palmberg, "Hydraulic transformers-comparison of different designs," 2004.

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